People

Eugene Shakhnovich

shakhnovich@chemistry.harvard.edu

Roy G. Gordon Professor of Chemistry

Arthur Bigot

arthurbigot@fas.harvard.edu

Visiting Scholar

I am a Data Science master’s student at ETH Zurich with a background in neuroscience, biology, and machine learning. I am interested in interpretability, AI safety, and biosecurity, with a focus on building robust and trustworthy models for biological...

Aniruddha Chattaraj

achattaraj@fas.harvard.edu

Post-Doctoral Fellow

Department of Chemistry and Chemical Biology

I am broadly interested in the spatiotemporal organization of biomolecules inside the cell. My current project involves computational modeling of the multivalent protein clustering in the context of biomolecular condensate formation. I am curious to study...

Saadi El-Saadi

saadielsaadi@college.harvard.edu

AB/AM Student

At the Shakhnovich group, my research focuses on computational and theoretical modeling of evolutionary fitness landscapes and the investigation of how ruggedness, epistasis, and navigability shape evolutionary trajectories. By applying fitness landscape...

Jonathan Feldman

jonathanfeldman@fas.harvard.edu

Visiting Undergraduate Researcher

I am an undergraduate student at the Georgia Institute of Technology. I am interested in utilizing machine learning to model the structure and evolution of pathogenic proteins, aiming to aid in the development of novel therapeutics.

Marian Huot

mhuot@fas.harvard.edu

Visiting Scholar

I am interested in modeling how viral proteins evolve under immune pressure by integrating biophysical constraints. My research combines statistical physics, machine learning, and experimental validation to predict antibody escape and optimize therapeutic...

Jio Jeong

Graduate Student

Department of Chemistry and Chemical Biology

I am interested in metabolons and understanding how those transient multi-protein complexes speed up metabolic flux in the living cell.

Junlang Liu

junlangliu@fas.harvard.edu

Graduate Student

Department of Chemistry and Chemical Biology

I am broadly interested in understanding biological phenomena using methods and concepts from physics. My current research focuses on the dynamics of intrinsically disordered proteins (IDPs) and its relation to evolution. Using theoretical and...

Antoine Maechler

antoinemaechler@fas.harvard.edu

Visiting Scholar

I am a master's student from Ecole Polytechnique, France. I'm interested in applications of AI and Geometric Deep Learning to protein-related problems and AI-driven drug discovery. I also study issues of multimodality, robustness, and interpretability in...

Vaibhav Mohanty

mohanty@hms.harvard.edu

Graduate Student

Department of Chemistry and Chemical Biology

Harvard-MIT MD-PhD Program

My work introduced the foundations of fitness landscape design (FLD), my new approach to shape the evolutionary landscape of proteins to fight disease. Using FLD, I design "evolutionary traps" —for example, using antibodies—to combat the rapid evolution...

Sayantan Mondal

smondal@fas.harvard.edu

Post-doctoral Fellow

Research Interest: liquid-liquid phase separation (LLPS) of intrinsically disordered polypeptides (IDPs) by employing coarse-grained (or generic model-based) molecular simulation techniques and tools from statistical mechanics.