Energy profile of the space of model protein sequences.
Publication information:
Tiana, G., Broglia, R. A. & Shakhnovich, E. I. Energy profile of the space of model protein sequences. Journal of biological physics 27, 147–59 (2001).
Abstract
A numerical study of the energy landscape of the space of model proteinsequences is carried out. As a consequence of the heterogeneity of thecontact energies among amino acids, the energy landscape displays a veryrough profile, a behaviour typical of frustrated systems. This givesraise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.