@article {101336,
	title = {Modeling the Kinetics of Acylation of Insulin using a Recursive Method for Solving the Systems of Coupled Differential Equations},
	journal = {Biophysical Journal},
	volume = {78},
	year = {2000},
	month = {2000},
	pages = {652 - 661},
	abstract = {This paper describes a theoretical method for solving systems of coupled differential equations that describe the kinetics of complicated reaction networks in which a molecule having multiple reaction sites reacts irreversibly with multiple equivalents of a ligand (reagent). The members of the network differ in the number of equivalents of reagent that have reacted, and in the patterns of sites of reaction. A recursive algorithm generates series, asymptotic, and average solutions describing this kinetic scheme. This method was validated by successfully simulating the experimental data for the kinetics of acylation of insulin.},
	url = {http://dx.doi.org/10.1016/S0006-3495(00)76623-9},
	author = {Bartosz A. Grzybowski and Anderson, Janelle R. and Colton, Ian and Brittain, Scott T. and Eugene I. Shakhnovich and George M. Whitesides}
}
