@article {101006,
	title = {Thymic Selection of T-Cell Receptors as an Extreme Value Problem},
	journal = {Phys. Rev. Lett.},
	volume = {103},
	year = {2009},
	month = {2009},
	pages = {068103},
	abstract = {T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions).},
	url = {http://dx.doi.org/10.1103/PhysRevLett.103.068103},
	author = {Ko{\v s}mrlj, Andrej and Chakraborty, Arup K. and Kardar, Mehran and Eugene I. Shakhnovich}
}
